Category: Various positive properties

Ionizing radiation (IR) can pass through the human body easily, potentially causing severe damage to all biocomponents, which is associated with increasing oxidative stress. IR is employed in radiotherapy; however, in order to increase safety, it is necessary to minimize side effects through the use of radioprotectors. Water-soluble derivatives of fullerene exhibit antiradical and antioxidant… Continue reading Fullerenol C₆₀(OH)₃₆ Protects the Antioxidant Enzymes in Human Erythrocytes against Oxidative Damage Induced by High-Energy Electrons

Fullerenol, a functional and water-soluble fullerene derivative, plays an important role in antioxidant, antitumor and antivirus, implying its enormous potential in biomedical applications. However, the in vivo performance of fullerenol remains largely unclear. We aimed to investigate the effect of fullerenol (i.p., 5 mg/kg) on the impaired hippocampus in a rat model of lead exposure.… Continue reading Long-term maintenance of synaptic plasticity by Fullerenol Ameliorates lead-induced-impaired learning and memory in vivo

Age-related macular degeneration (AMD) causes central vision impairment with increased incidence. In the pathogenesis of AMD, reactive oxygen species (ROS) are associated with RPE cell apoptosis. H2O2 is an oxidative toxicant and is used to establish the AMD in vitro model. However, the mechanisms of ROS in H2O2-induced AMD are still unclear. Fullerenol, a promising antioxidant of nanomaterials,… Continue reading The transcriptome profile of RPE cells by the fullerenol against hydrogen peroxide stress

The eyes are highly susceptible to the oxidative stress induced by ultraviolet B (UVB, wavelength between 280 ∼ 320 nm), which could cause severe damage to the cornea. Fullerenols are effective antioxidants to alleviate UVB-induced injury, while their application for the eyes is still rare. In present study, we investigated the protective performance and mechanism… Continue reading Fullerenol protects cornea from ultraviolet B exposure

Fullerene is a nanosized carbon structure with potential drug delivery applications. We studied the bioeffects of a water-soluble fullerene derivative, fullerenol, with 10-12 oxygen groups (F10-12); its structure was characterized by IR and XPS spectroscopy. A bioluminescent enzyme system was used to study toxic and antioxidant effects of F10-12 at the enzymatic level. Antioxidant characteristics… Continue reading Toxicity and Antioxidant Activity of Fullerenol C_60,70 with Low Number of Oxygen Substituents

In this perspective we first examine the rich physicochemical properties of dendritic polymers for hosting cations, anions, and polyaromatic hydrocarbons. We then extrapolate these conceptual discussions to the use of dendritic polymers in humic acid antifouling, oil dispersion, copper sensing, and fullerenol remediation. In addition, we review the state-of-the-art of dendrimer research and elaborate on… Continue reading Exploiting the physicochemical properties of dendritic polymers for environmental and biological applications

During cancer development, the fibrous layers surrounding the tumor surface get thin and stiff which facilitates the tumor metastasis. After the treatment of metallofullerene derivatives Gd@C82(OH)22, the fibrous layers become thicker and softer, the metastasis of tumor is then largely suppressed. The effect of Gd@C82(OH)22 was found to be related to their direct interaction with… Continue reading Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules

It has been shown by fluorescence analysis in vitro that the water-soluble sodium salt of the polycarboxylic derivative of fullerene C60, fullerenol, and complexes of fullerene C60 with polyvinylpyrrolidone (mol. wt. 25000 and 10000) destroy amyloid fibrils of the brain peptide Abeta(1-42) and prevent their formation. The results of fluorescence analysis confirmed the data obtained… Continue reading Fluorescence analysis of the action of soluble derivatives of fullerene C60 on amyloid fibrils of the brain peptide Abeta(1-42)

Fullerenols, the water-soluble derivatives of fullerenes, are currently being recently intensively studied in the context of the possibility of their application in the biomedicine. Due to their hydrophilic properties and the ability to eliminate free radicals, fullerenols may in the future provide a solid alternative to currently used pharmacological methods in chemotherapy, treatment of neurodegenerative… Continue reading Fullerenol – properties and applications in biomedical sciences

Inhibition of PTP1B by polyhydroxylated fullerenes was studied in silico and in vitro. The enzyme kinetics in the presence of polyhydroxy small gap fullerenes showed that reciprocal value of maximum velocity non-linearly increases with increasing the inhibitor concentration. Analysis of the dose-dependent curve of PTP1B inhibition suggests an apparent positive cooperativity with involvement of at… Continue reading INHIBITORY POTENTIAL OF POLYHYDROXYLATED FULLERENES AGAINST PROTEIN TYROSINE PHOSPHATASE 1B

Polyhydroxylated derivatives of fullerene C60, named fullerenols (C60[OH]n), have stimulated great interest because of their potent antioxidant properties in various chemical and biological systems, which enable them to be used as a new promising pharmaceutical for the future treatment of oxidative stress-related diseases, but the details remain unknown. Nuclear factor erythroid 2-related factor 2 (Nrf2)… Continue reading Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system

Water-solubilization is the prerequisite to endow the pristinely hydrophobic fullerenes with biocompatibility and biofunctionality, which has been widely applied to derive fullerene-based nanomaterials for biomedical applications. Oxidation reactions using O2 and H2O2 are the most commonly used approaches to this end, through which fullerenols with different structural features can be obtained. Despite the progress in… Continue reading Oxidation-induced water-solubilization and chemical functionalization of fullerenes C60, Gd@C60 and Gd@C82: atomistic insights into the formation mechanisms and structures of fullerenols synthesized by different methods

Neuroprotective properties of fullerenols С60(OH)30#nbsp;and С70(OH)30#nbsp;have been shown in a Drosophila melanogaster model of Parkinson’s Disease (PD). Fullerenols used in this work demonstrated negligible toxicity even at high concentrations as a result of a specifically developed manufacturing process. It has been shown that the drugs promote restoration of dopamine levels, reduce oxidative stress in transgenic… Continue reading The neuroprotective effect of fullerenols on a model of Parkinson’s disease in Drosophila melanogaster

Accumulated evidence suggests a pathogenic role of reactive oxygen species (ROS) in perpetually rheumatoid joints. Therefore, the application of radical scavengers for reducing the accumulation of ROS is beneficial for patients with rheumatoid arthritis (RA). We synthesized water-soluble fullerenols that could inhibit the production of ROS and applied intra-articular (i.a.) injection in an experimental arthritis… Continue reading Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol

The enormous progress in nanomaterials development and their use, followed by their inevitable environmental print, has arisen the emerging questions concerning their influence to the living systems. Honey bees are considered to be quite a suitable model system for the risk assessment and prediction of various external influences. To the best of our knowledge, this… Continue reading Effect of fullerenol nanoparticles on oxidative stress induced by paraquat in honey bees

Using a novel hydrogen peroxide heating method, we synthesized milky white, water-soluble polyhydroxylated fullerenes (fullerenols) with 36-40 hydroxyl groups (estimated average) along with 8-9 secondary bound water molecules. The fullerenols exhibited high water solubility up to 58.9 mg/mL in a neutral (pH = 7) condition. Dynamic light scattering analysis showed a high dispersion property, to… Continue reading Facile synthesis of highly water-soluble fullerenes more than half-covered by hydroxyl groups

Fullerenol (F) shows a strong and stable room-temperature phosphorescence (RTP) signal on the surface of nitrocellulose membrane (NCM) at lambda ex max/ lambda em max =542.0/709.4 nm. When modified by dodecylbenzenesulfonic acid sodium salt (DBS), fullerenol emits a stronger signal. It was also found that quantitative specific affinity-adsorption reaction can be carried out between Triticum… Continue reading Determination of trace alkaline phosphatase by solid-substrate room-temperature phosphorimetry based on Triticum vulgare lectin labeled with fullerenol

The potential biomedical applications of fullerenol C(60)(OH)(x) (x≈24) have been extensively studied. However, the structural information of the interaction of fullerenol with the bio-system at the molecular level, which is essential for understanding its bioactivity and toxicity, is still missing. In this study, lysozyme was selected as a model protein to investigate the interaction between… Continue reading Interaction of fullerenol with lysozyme investigated by experimental and computational approaches

We investigate the impact of hydroxyl groups on the properties of C(60)(OH)(n) systems, with n = 1, 2, 3, 4, 8, 10, 16, 18, 24, 32 and 36 by means of first-principles density functional theory calculations. A detailed analysis from the local density of states has shown that adsorbed OH groups can induce dangling bonds… Continue reading Effects of hydroxyl group distribution on the reactivity, stability and optical properties of fullerenols

Fullerenes, also known as buckyballs, are spheroidal carbon cages with a molecular formula of C2n#nbsp;(n#nbsp;= 30–41) and a diameter of ~1 nm (1). The high chemical stability of fullerenes can resist any potential metabolic cage-opening process and hence prevents them from degradation in various biological conditions (2). Fullerenes contain hollow interiors that can hold atoms… Continue reading Gd@C 82 Fullerenol

A mild and facile process for the preparation of 1,4-fullerenols C(60)ArOH was achieved. The key intermediate 1,2-C(60)Ar(NO(2)) was identified to better understand the reaction mechanism. Further functionalizations including esterification, etherification, and arylation of the synthesized 1,4-C(60)ArOH provided efficient access to versatile fullerene derivatives in the presence of p-toluenesulfonic acid. https://pubmed.ncbi.nlm.nih.gov/19265412/

A fullerenol-based synthetic sweetness receptor model, consisting of polyhydroxy groups for potential hydrogen bond donor along with a spherical hydrophobic center, was proposed according to the widely accepted sweetness hypothesis. An isothermal titration calorimetry (ITC) technique was used to study mimetic interaction of this sweet receptor model with a series of sweeteners having increasing sweetness… Continue reading Isothermal titration calorimetry study of the interaction of sweeteners with fullerenols as an artificial sweet taste receptor model

We provide the first evidence that a fullerene derivative can be extensively mineralized under environmental conditions by direct photolysis. Dissolved inorganic carbon (DIC) was identified as a major photoproduct of fullerenol, a hydroxylated C(60) molecule and the ratio of moles DIC produced to moles of fullerenol reacted reached 28 or approximately 47% of complete mineralization… Continue reading Light-initiated transformations of fullerenol in aqueous media

In spite of extensive studies on their preparation and application, the precise structure of fullerenols remains unknown. Fullerenols used in all the known studies are complicated mixtures of compounds. It is impossible to isolate isomerically pure fullerenols even after exhaustive purification procedures. Thus, the exact number of OH groups and their relative locations on the… Continue reading Facile synthesis of isomerically pure fullerenols and formation of spherical aggregates from C60(OH)8

In this study, we systematically investigated the interaction of fullerenes/fullerenols with model proteins using a widely used computational docking program Autodock 4.0. We found that pi-pi interaction existed in all the proteins-fullerene/fullerenol systems investigated here, and contributed greatly to the overall interaction energy. We also found that with the increase of the carbon cage size,… Continue reading Influences of the size and hydroxyl number of fullerenes/fullerenols on their interactions with proteins

Fullerenols have been a subject of intense research in many fields with the claim of possible applications in biomedicine such as free-radical sponges, antioxidants, and photosensitizers. However, its transport characteristics, important in determining the feasibility of many applications, have not been studied yet. In this work, electrochemical impedance of aqueous solutions of two types of… Continue reading Nonlinear conductivity of fullerenol aqueous solutions

The nanosystem composed of only as few as seven fullerenols C(60)(OH)(24) molecules was studied using the molecular dynamics (MD) technique. The interaction was taken to be the full site-site pairwise additive Lennard-Jones (LJ) potential, which generates both translational and anisotropic rotational motions of each fullerenol. The radial distribution function, the mean square displacement, the Lindemann… Continue reading The properties of small fullerenol cluster (C60(OH)24)7: computer simulation

The potential nitric oxide scavenging activity of polyhydroxylated derivative of fullerene C(60)(OH)(24), called fullerenol, has been tested using the computer simulation (MD) method. The study is motivated by the expected diverse biological applications of water-soluble fullerenols. The static structure factor of the nitric oxide and fullerenol mixture in water solvent, related to the neutron scattering… Continue reading The structural studies of fullerenol C60(OH)24 and nitric oxide mixture in water solvent – MD simulation

The aim of the present study was to produce monoclonal anti-fullerene C(60) antibodies and to develop the enzyme immunoassay for the detection in the first use of free fullerene C(60) both in solutions and in multicomponent biological probes. The immunization of mice with the conjugate of fullerene C(60) carboxylic derivative with thyroglobulin synthesized by carbodiimide… Continue reading Production of monoclonal antibodies against fullerene C60 and development of a fullerene enzyme immunoassay