Tag: Various positive properties

The potential nitric oxide scavenging activity of polyhydroxylated derivative of fullerene C(60)(OH)(24), called fullerenol, has been tested using the computer simulation (MD) method. The study is motivated by the expected diverse biological applications of water-soluble fullerenols. The static structure factor of the nitric oxide and fullerenol mixture in water solvent, related to the neutron scattering… Continue reading The structural studies of fullerenol C60(OH)24 and nitric oxide mixture in water solvent – MD simulation

The aim of the present study was to produce monoclonal anti-fullerene C(60) antibodies and to develop the enzyme immunoassay for the detection in the first use of free fullerene C(60) both in solutions and in multicomponent biological probes. The immunization of mice with the conjugate of fullerene C(60) carboxylic derivative with thyroglobulin synthesized by carbodiimide… Continue reading Production of monoclonal antibodies against fullerene C60 and development of a fullerene enzyme immunoassay

Experiments have shown that two water-soluble fullerene C(60) derivatives, fullerenol and fullerene trimalonic acid, inhibit duplication of DNA via polymerase chain reaction (PCR). It has further been shown that the target of this inhibition is the DNA polymerase protein routinely used in PCR. We have used a combination of molecular docking and molecular dynamics simulations… Continue reading Mechanism of taq DNA polymerase inhibition by fullerene derivatives: insight from computer simulations

Reactive oxygen species (ROS) are one of the most important intermediates in chemical, photochemical, and biological processes. To understand the environmental exposure and toxicity of fullerenes better, the production and consumption of ROS (singlet oxygen, superoxide, hydrogen peroxide, and hydroxyl radicals) by Buckminster fullerene (C(60) ) and fullerenol were investigated in aqueous systems. Fullerenol exhibits… Continue reading Production and consumption of reactive oxygen species by fullerenes

Nanoscale assembly is an area of research that has vast implications for molecular design, sensing, nanofabrication, supramolecular chemistry, catalysis, and environmental remediation. Here we show that poly(amidoamine) (PAMAM) dendrimers of both generations 1 (G1) and 4 (G4) can host 1 fullerenol per 2 dendrimer primary amines as evidenced by isothermal titration calorimetry, dynamic light scattering… Continue reading Dendrimer-Fullerenol Soft-Condensed Nanoassembly

Oxidative stress has an important role in the pathogenesis of doxorubicin (DOX)-induced nephrotoxicity. The aim of this study was to investigate the nephroprotective effects of fullerenol (FLR), an antioxidant agent, on DOX-induced nephrotoxicity. The investigation was carried out on adult female Sprague Dawley outbred rats with chemically induced breast cancer (1-methyl-1-nitrosourea; 50 mg/kg; ip). Rats… Continue reading Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C60(OH)24 via suppression of oxidative stress

Development of novel anti-inflammatory drugs is an important issue. One mechanism by which inflammation can be attenuated is by elimination of ROS and free radicals [17,18]. Fullerenes, a recently discovered allotrope of carbon [19], have attracted much attention in pharmacology as reviewed [20]. Fullerenes, also termed buckminsterfullerenes or simply ‘bucky balls’ [21], are molecules consisting… Continue reading Polyhydroxylated C60 fullerene (fullerenol) attenuates neutrophilic lung inflammation in mice

The antimicrobial activities of fullerene C60 and its derivatives against 6 kinds of bacteria and 2 kinds of fungi were evaluated. The tested samples were water-soluble fullerenes (polyvinylpyrrolidone (PVP)/C60, gamma-cyclodextrin (gamma-CD)/C60, and nano-C60) and 3 types of fullerenols (C60(OH)12, C60(OH)36.8H2O, and C60(OH)44.8H2O). Their activities were compared with those of (+)-catechin and hinokitiol from the viewpoint… Continue reading Antimicrobial activity of fullerenes and their hydroxylated derivatives

Polyhydroxylated fullerenes (fullerenols: C(60)(OH)(n)) are known as the major water-soluble fullerene derivatives which possess particular significance as free radical scavengers or antioxidants in biological systems. Recently, the novel polyhydroxylated fullerene (C(60) (OH)(44)·8H(2)O: SHH-F) was successfully synthesized. In the present study, we investigated the radical-scavenging effects and cytoprotective effects of three types of fullerenols (C(60)(OH)(6-12): LH-F,… Continue reading Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages

Recent toxicological studies on carbon nanomaterials, including fullerenes, have led to concerns about their safety. Functionalized fullerenes, such as polyhydroxy fullerenes (PHF, fullerols, or fullerenols), have attracted particular attention due to their water solubility and toxicity. Here, we report surprisingly beneficial and/or specific effects of PHF on model organisms representing four kingdoms, including the green… Continue reading Polyhydroxy fullerenes (fullerols or fullerenols): beneficial effects on growth and lifespan in diverse biological models

The polymeric permiselective membranes application for immunoisolation of cells separating the transplanted cells from the host immunological system may eliminate immunosuppressive therapy during transplantation. The suitability of polyelectrolyte modified nanocoatings for immunoisolation of cells was assessed. The polymeric shells modified with incorporated fullerene derivate were applied for encapsulation of human T-lymphocyte cell line Jurkat or… Continue reading Suitability of polyelectrolyte shells modified with fullerene derivate for immunoisolation of cells. Experimental study

Oxidative stress plays a major role in acne formation; this suggests that oxygen-radical scavengers could be potential therapeutic agents. Fullerenol C60(OH)44, a recently developed polyhydroxylated fullerene, is a spherical carbon molecule that has many hydroxyl groups capable of potent radical-scavenging activity. We have investigated its inhibitory effects in vitro on sebum production in hamster sebocytes… Continue reading Inhibition of sebum production and Propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: potential as a therapeutic reagent for acne

Native fullerene is notoriously insoluble in water and forms aggregates toxic to cell membranes, thus limiting its use in nanomedicine. In contrast, water-soluble fullerenol is compatible with biological systems and shows low in vivo toxicity on human cell lines. The interaction mechanism between these hydrophilic nanoparticles and biological membranes is however not well understood. Therefore,… Continue reading Comparative study of the interaction of fullerenol nanoparticles with eukaryotic and bacterial model membranes using solid-state NMR and FTIR spectroscopy

Recently, much attention has been paid to the bioactive properties of water-soluble fullerene derivatives: fullerenols, with emphasis on their pro- and antioxidative properties. Due to their hydrophilic properties and the ability to scavenge free radicals, fullerenols may, in the future, provide a serious alternative to the currently used pharmacological methods in chemotherapy, treatment of neurodegenerative… Continue reading Fullerenols as a new therapeutic approach in nanomedicine

Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses to the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing the antigen dosage and immunization frequency while maintaining immunity levels and inducing TEM -biased immunity to combat the infection at early stage. The… Continue reading Morphologically virus-like fullerenol nanoparticles act as the dual-functional nanoadjuvant for HIV-1 vaccine

The present study was aimed at investigating the effect of fullerenol C60(OH)36 on chosen parameters of the human erythrocyte membrane and the preliminary estimation of the properties of fullerenol as a potential linking agent transferring the compounds (e.g., anticancer drugs) into the membrane of erythrocytes. The results obtained in this study confirm the impact of… Continue reading Fullerenol C₆₀(OH)₃₆ could associate to band 3 protein of human erythrocyte membranes

Purpose:#nbsp;Oxidative stress-induced retinal pigment epithelium (RPE) senescence is one of the important factors in the pathogenesis of age-related macular degeneration (AMD). This study aimed to develop a new antisenescence-based intervention and clarify its possible molecular mechanism. Methods:#nbsp;A cell premature senescence model was established in both primary RPE cells and ARPE-19 cells by exposure of the… Continue reading Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating SIRT1

The infrared and Raman spectra of C60(OH)24 molecule with uniform and non-uniform distribution of hydroxyl groups have been investigated using first principle DFT calculations at the B3LYP/6-31G(d,p) level of theory. The important features of the obtained geometries have been measured and compared to experimental results. The reference calculations of C60 molecule geometry and vibrational spectra… Continue reading The influence of distribution of hydroxyl groups on vibrational spectra of fullerenol C60(OH)24 isomers: DFT study

Fullerenols are polyhydroxylated, water soluble derivatives of fullerene C60, with potential application in medicine as diagnostic agents, antioxidants or nano drug carriers. This paper describes synthesis and physical characterization of a new nanocomposite hydroxyapatite/fullerenol. Surface of the nanocomposite hydroxyapatite/fullerenol is inhomogeneous with the diameter of the particles in the range from 100 nm to 350… Continue reading Synthesis and Characterization of Hydroxyapatite/Fullerenol Nanocomposites

In this study, we presented an investigation of mechanical properties by AFM nanoindentation on human hepatocellular carcinoma cells treated with fullerenol for 24, 48 and 72 h. AFM nanoindentation was routinely applied to investigate the morphology and biomechanical properties of living carcinoma cells, and adhesion phenomena (negative force) were detected in the obtained force-displacement curves.… Continue reading Investigation of work of adhesion of biological cell (human hepatocellular carcinoma) by AFM nanoindentation

Since their discovery, fullerenes, carbon nanotubes, and graphene attract significant attention of researches in various scientific fields including biomedicine. Nano-scale size and a possibility for diverse surface modifications allow carbon nanoallotropes to become an indispensable nanostructured material in nanotechnologies, including nanomedicine. Manipulation of surface chemistry has created diverse populations of water-soluble derivatives of fullerenes, which… Continue reading Carbon nanomaterials: Biologically active fullerene derivatives

In this work structuring of water and insight into intermolecular interactions between water and fullerenol are studied throughout the process of forming nanoagglomerates at different temperatures applying both experimental and computational approaches. The obtained fullerenol nanoparticles (FNPs) are firstly characterized using dynamic light scattering, atomic force microscopy and transmission electron microscopy. The density, electrical conductivity… Continue reading Self-assembling, reactivity and molecular dynamics of fullerenol nanoparticles

Fullerenols are water-soluble analogs of fullerene exhibiting both antioxidant and prooxidant activities in vitro and in vivo. Here we report, for the first time, that fullerenol C60(OH)24 can induce ion permeability of a planar lipid bilayer membrane via the formation of ion pores or conductive defects with a preference for cations over anions. The fullerenol-mediated… Continue reading Fullerenol C60(OH)24 increases ion permeability of lipid membranes in a pH-dependent manner

A convenient and highly efficient palladium-catalyzed reaction of [60]fullerene (C60) with aroyl compounds via enolate-mediated C-H activation and hydroxylation has been exploited for the first time to synthesize novel C60-fused dihydrofurans, and rare 1,4-fullerenols. Further functionalization including etherification, and esterification of synthesized 1,4-fullerenols provided efficient access to versatile fullerene derivatives. Moreover, a plausible reaction mechanism… Continue reading Palladium-Catalyzed Reaction of [60]Fullerene with Aroyl Compounds via Enolate-Mediated sp 2 C-H Bond Activation and Hydroxylation

The surface modification of commercial TiO2#nbsp;Hombikat (TiO2) using nanoparticles of fullerene C60#nbsp;with tetrahydrofuran (THF-nC60), as well as fullerenol C60(OH)24#nbsp;nanoparticles (FNP) was investigated in this study. Characterization of THF-nC60, FNP, TiO2, TiO2/THF-nC60, and TiO2/FNP was studied by using DES, ELS, TEM, SEM, DRS and BET measurements and their photoactivity has been examined on the mesotrione degradation… Continue reading Enhancement of nano titanium dioxide coatings by fullerene and polyhydroxy fullerene in the photocatalytic degradation of the herbicide mesotrione

In the present work, the novel dense and supported membranes based on polyvinyl alcohol (PVA) with improved transport properties were developed by bulk and surface modifications. Bulk modification included the blending of PVA with chitosan (CS) and the creation of a mixed-matrix membrane by introduction of fullerenol. This significantly altered the internal structure of PVA… Continue reading Development and Characterization of New Pervaporation PVA Membranes for the Dehydration Using Bulk and Surface Modifications

Fullerenols have been known for decades; however, the photoluminescent (PL) properties and applications in supramolecular chemistry of these molecules have not been well addressed. Herein, a strategy has been developed to purify the as-prepared fullerenols, and the photoluminescence and capabilities of these molecules to form supramolecular self-assemblies were systematically studied. It was found that fullerenols… Continue reading Fullerenols Revisited: Highly Monodispersed Photoluminescent Nanomaterials as Ideal Building Blocks for Supramolecular Chemistry

This study focuses first on the preparation of mixed matrix supported membranes of polyvinyl alcohol (PVA) and low-hydroxylated fullerenol C60(OH)12#nbsp;used to create water selective membranes and then on their pervaporation properties for the separation of water-THF mixtures. These novel supported PVA membranes containing nano-carbon particles were prepared to reach high membrane performance for further integration… Continue reading Novel green PVA-fullerenol mixed matrix supported membranes for separating water-THF mixtures by pervaporation

Pulmonary fibrosis has become a fatal disease for its high incidence and few effective drugs available in clinic. In this study, gadofullerenol (GF-OH) and [70] fullerenol (C70-OH) nanoparticles (NPs) prepared by a one-pot reaction were designed as nanomedicines to treat this fatal disease. It was revealed that the inhalation of gadofullerenols and [70] fullerenols substantially… Continue reading Inhalable gadofullerenol/[70] fullerenol as high-efficiency ROS scavengers for pulmonary fibrosis therapy

The importation of construction principles or even constituents from biology into materials science is a prevailing concept. Vice versa, the cellular level modification of living systems with nonnatural components is much more difficult to achieve. It has been done for analytical purposes, for example, imaging, to learn something about intracellular processes. Cases describing the improvement… Continue reading Increasing the Resistance of Living Cells against Oxidative Stress by Nonnatural Surfactants as Membrane Guards