The transcriptome profile of RPE cells by the fullerenol against hydrogen peroxide stress

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Age-related macular degeneration (AMD) causes central vision impairment with increased incidence. In the pathogenesis of AMD, reactive oxygen species (ROS) are associated with RPE cell apoptosis. H₂O₂ is an oxidative toxicant and is used to establish the AMD in vitro model. However, the mechanisms of ROS in H₂O₂-induced AMD are still unclear. Fullerenol, a promising antioxidant of nanomaterials, protects RPE cells from ROS attack. In addition to working as a scavenger, little is known about the antioxidant mechanism of fullerenol in RPE cells. In this study, transcriptome sequencing was performed to examine the global changes in mRNA transcripts induced by H₂O₂ in human ARPE-19 cells. Moreover, we comprehensively investigated the protective effects of fullerenol against H₂O₂-induced oxidative injury by RNA sequencing. Gene Ontology enrichment analysis showed that those pathways related to the release of positive regulation of DNA-templated transcription and negative regulation of apoptotic process were affected. Finally, we found that 12 hub genes were related to the oxidative-protection function of fullerenol. In summary, H₂O₂ affected these hub genes and signaling pathways to regulate the senescence of RPE cells. Moreover, fullerenol is a potent nanomaterial that protects the RPE and would be a promising approach for AMD prevention.

https://pubmed.ncbi.nlm.nih.gov/36186803/

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