Free United States and Australia Shipping

Our site uses cookies to make for a more optimal experience. By continuing to browse
the site you are agreeing to our use of cookies. You can view our cookie information here.

Cart 0
  • AUD$
  • USD$
Home Research

Investigation of fullerenol-induced changes in poroelasticity of human hepatocellular carcinoma by AFM-based creep tests


Link copied

In this study, atomic force microscopy (AFM) is used to investigate the alterations of the poroelastic properties of hepatocellular carcinoma (SMMC-7721) cells treated with fullerenol. The SMMC-7721 cells were subject to AFM-based creep tests, and a corresponding poroelastic indentation model was used to determine the poroelastic parameters by curve fitting. Comparative analyses indicated that the both permeability and diffusion of fullerenol-treated cells increased significantly while their elastic modulus decreased by a small amount. From the change in the trend of the determined parameter, we verified the corresponding alternations of cytoskeleton (mainly filaments actin), which was reported by the previous study using confocal imaging method. Our investigation on SMMC-7721 cell reveals that the poroelastic properties could provide a better understanding how the cancer cells are affected by fullerenol or potentially other drugs which could find possible applications in drug efficacy test, cancer diagnosis and secure therapies.

Related researches 41 articles

<strong>Exploring the World of Fullerenols: A Deep Dive into Their Potential Medical Use</strong>
Cancer / Transport / Delivery Various positive properties
Exploring the World of Fullerenols: A Deep Dive into Their Potential Medical Use
Caging cancer
Cancer / Transport / Delivery
Caging cancer