Abstract
Aim:#nbsp;The aim of this study is to demonstrate whether fullerenol C60 protects renal injury in sevoflurane‑administered rats.
Method:#nbsp;Rats (n: 24) were randomly divided into four groups: Control (Group C), Fullerenol C60 (Group F), Sevoflurane (Group S), Fullerenol C60-Sevoflurane (Group FS). Thirty minutes before the procedure, Fullerenol C60, 100 mg/kg, was administered intraperitoneally. Sevoflurane (2.3 %) was applied for 3 hours to rats in S and FS groups. Biochemical and histopathological parameters were analyzed in renal tissue samples. Kruskal-Wallis and Mann-Whitney U tests were used in statistical analyzes.
Results:#nbsp;Malondialdehyde (MDA) level and catalase (CAT) enzyme activity in Group S were significantly higher than that in all other groups. Paraoxanase (PON) enzyme activity in Group S was significantly lower than in Groups C and FS. The histopathological examination showed that vascular vacuolization and hypertrophy (VVH) and lymphocyte infiltration (LI) were significantly higher in the Group S compared to the Group C.
Conclusion:#nbsp;Renal histopathology revealed that the administration of Fullerenol C60 prior to sevoflurane inhalation reduced oxidative stress and partially corrected the damage caused by anesthesia. We concluded that Fullerenol C60 has a renal protective effect in rats when administered before sevoflurane anesthesia (Tab. 2, Fig. 4, Ref. 40).
Related researches 23 articles
Antioxidant properties / No toxicity / Safety
The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes
Antioxidant properties / No toxicity / Safety
Effect of fullerenol nanoparticles on oxidative stress induced by paraquat in honey bees
Antioxidant properties / No toxicity / Safety
The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity
Antioxidant properties / No toxicity / Safety
Antioxidant activity of highly hydroxylated fullerene C60 and its interactions with the analogue of α-tocopherol
Antioxidant properties / No toxicity / Safety
Antioxidant Activity and Toxicity of Fullerenols via Bioluminescence Signaling: Role of Oxygen Substituents
Antioxidant properties / No toxicity / Safety
The neuroprotective effect of fullerenols on a model of Parkinson’s disease in Drosophila melanogaster
Antioxidant properties / No toxicity / Safety
In vitro and in vivo study of the toxicity of fullerenols С 60, С 70 and С 120 О obtained by an original two step method
Antioxidant properties / No toxicity / Safety
Toxicity of functionalized fullerene and fullerene synthesis chemicals
Antioxidant properties / No toxicity / Safety
Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells
Antioxidant properties / No toxicity / Safety
Mechanisms of Antioxidant Activities of Fullerenols from First-Principles Calculation
Antioxidant properties / No toxicity / Safety
Fullerenol nanoparticles prevents doxorubicin-induced acute hepatotoxicity in rats
Antioxidant properties / No toxicity / Safety
Effects of Fullerenols on Mouse Brain Microvascular Endothelial Cells
Antioxidant properties / No toxicity / Safety
Mechanism of ROS scavenging and antioxidant signalling by redox metallic and fullerene nanomaterials: Potential implications in ROS associated degenerative disorders
Antioxidant properties / No toxicity / Safety
Bioluminescent Enzymatic Assay as a Tool for Studying Antioxidant Activity and Toxicity of Bioactive Compounds
Antioxidant properties / No toxicity / Safety
Effects of fullerenol nanoparticles on acetamiprid induced cytoxicity and genotoxicity in cultured human lung fibroblasts
Antioxidant properties / No toxicity / Safety
Fullerenol nanoparticles: toxicity and antioxidant activity
Antioxidant properties / No toxicity / Safety
Gene expression and biochemical responses in brain of zebrafish Danio rerio exposed to organic nanomaterials: carbon nanotubes (SWCNT) and fullerenol (C60(OH)18-22(OK4))
Antioxidant properties / No toxicity / Safety
Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability
Antioxidant properties / No toxicity / Safety
Effect of fullerenol C(60)(OH) (24) on lipid peroxidation of kidneys, testes and lungs in rats treated with doxorubicine
Antioxidant properties / No toxicity / Safety
Effects of fullerenol C60(OH)24 on the frequency of micronuclei and chromosome aberrations in CHO-K1 cells
Antioxidant properties / No toxicity / Safety
Fullerenol C60(OH)24 prevents doxorubicin-induced acute cardiotoxicity in rats
