Free United States and Australia Shipping

Our site uses cookies to make for a more optimal experience. By continuing to browse
the site you are agreeing to our use of cookies. You can view our cookie information here.

Cart 0
USD$
  • AUD$
  • USD$
Home Research

Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability

Share:

Link copied

Background:#nbsp;Recent studies have shown that the biological actions and toxicity of the water-soluble compound, polyhydroxyfullerene (fullerenol), are related to the concentrations present at a particular site of action. This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons.

Methods and results:#nbsp;Fullerenol at low concentrations significantly enhanced hippocampal neuron viability as tested by MTT assay and Hoechst 33342/propidium iodide double stain detection. At high concentrations, fullerenol induced apoptosis confirmed by Comet assay and assessment of caspase proteins.

Conclusion:#nbsp;These findings suggest that fullerenol promotes cell death and protects against cell damage, depending on the concentration present. The concentration-dependent effects of fullerenol were mainly due to its influence on the reduction-oxidation pathway.

https://pubmed.ncbi.nlm.nih.gov/22802681/

Related researches 23 articles

Effects of Fullerenols on Mouse Brain Microvascular Endothelial Cells
Antioxidant properties / No toxicity / Safety
Effects of Fullerenols on Mouse Brain Microvascular Endothelial Cells
On mechanism of antioxidant effect of fullerenols
Antioxidant properties / No toxicity / Safety
On mechanism of antioxidant effect of fullerenols
Fullerenol nanoparticles: toxicity and antioxidant activity
Antioxidant properties / No toxicity / Safety
Fullerenol nanoparticles: toxicity and antioxidant activity