The aim of this study was to investigate the possible protective role of fullerenol (FLR, C(60)(OH)(24) on doxorubicin (DOX)-induced lung toxicity using biochemical and histopathological approaches. Rats (Sprague-Dawley outbred) were randomly divided into five groups. The healthy control group received no medication (saline only). The other four groups had chemically induced breast cancer (1-methyl-1-nitrosourea; 50 mg/kg, ip). The second group was the cancer control group (saline only). The other three groups were DOX (8 mg/kg, ip), FLR/DOX (100 mg/kg, ip, 30 min before DOX; 8 mg/kg, ip), and FLR (100 mg/kg, ip), respectively. The levels of malondialdehyde (MDA) and oxidized glutathione (GSSG) in the lung tissue were higher in the group treated with DOX alone than in the control groups. The activities of catalase (CAT), glutathione reductase (GR), superoxide dismutase (SOD), and lactate dehydrogenase (LDH) were found to be increased in the lung tissue of the animals in the DOX group over all the other groups, while GSH-Px significantly decreased in activity compared with the control and FLR groups. There was no significant difference in MDA and GSSG levels and enzyme activities in either control (healthy; cancer) or FLR (FLR/DOX; FLR) groups. The acute change found in the DOX group was subpleural edema. In contrast, the groups treated with FLR appeared to be virtually histopathologically normal. In conclusion, this study clearly indicates that DOX treatment markedly impairs pulmonary function and that pre-treatment with FLR might prevent this toxicity in rats through inhibition of oxidative stress.
Related researches 41 articles
![<strong>Exploring the World of Fullerenols: A Deep Dive into Their Potential Medical Use</strong>](https://biofullerene.com/wp-content/uploads/2024/03/20-years-research-help-with-oncology-356x356.webp)
![Biological and biocompatible characteristics of fullerenols nanomaterials for tissue engineering](https://biofullerene.com/wp-content/uploads/2022/12/photo_2022-12-29_12-06-18-500x317.jpg)
![Small size fullerenol nanoparticles suppress lung metastasis of breast cancer cell by disrupting actin dynamics](https://biofullerene.com/wp-content/uploads/2022/11/ImageForArticle_4620-500x333.jpg)
![Fullerenol C60(OH)24 effects on antioxidative enzymes activity in irradiated human erythroleukemia cell line](https://biofullerene.com/wp-content/uploads/2022/11/212206-356x356.png)
![Antioxidant properties of fullerenol C60(OH)24 in rat kidneys, testes, and lungs treated with doxorubicin](https://biofullerene.com/wp-content/uploads/2022/11/cancer-icon-2797418_-356x356.png)
![Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis](https://biofullerene.com/wp-content/uploads/2022/11/targeted-drug-delive-356x356.jpg)
![AFM-based study of fullerenol (C60(OH)24)-induced changes of elasticity in living SMCC-7721 cells](https://biofullerene.com/wp-content/uploads/2022/11/depositphotos_352541-356x356.jpg)
![Fullerenes and their derivatives as inhibitors of tumor necrosis factor-α with highly promoted affinities](https://biofullerene.com/wp-content/uploads/2022/11/0005-009-poluchenie--475x356.jpg)
![Fullerenol/doxorubicin nanocomposite mitigates acute oxidative stress and modulates apoptosis in myocardial tissue](https://biofullerene.com/wp-content/uploads/2022/11/heartAttackCardiacAr-500x346.jpg)
![Hydrophobic Patch of Ubiquitin is Important for its Optimal Activation by Ubiquitin Activating Enzyme E1](https://biofullerene.com/wp-content/uploads/2022/11/1725885-500x263.png)
![Biocompatible [60]/[70] Fullerenols: Potent Defense against Oxidative Injury Induced by Reduplicative Chemotherapy](https://biofullerene.com/wp-content/uploads/2022/11/istockphoto-65584859-356x356.jpg)
![Aspartic acid derivatized hydroxylated fullerenes as drug delivery vehicles for docetaxel: an explorative study](https://biofullerene.com/wp-content/uploads/2022/11/1200px-L-Asparaginsu-500x295.png)
![Study of morphological and mechanical features of multinuclear and mononuclear SW480 cells by atomic force microscopy](https://biofullerene.com/wp-content/uploads/2022/11/5AawkyZS8dY7T9C3AZwH-474x356.jpg)
![Molecular mechanism of Gd@C 82(OH) 22 increasing collagen expression: Implication for encaging tumor](https://biofullerene.com/wp-content/uploads/2022/11/4264665-356x356.png)
![Metallofullerenol Inhibits Cellular Iron Uptake by Inducing Transferrin Tetramerization](https://biofullerene.com/wp-content/uploads/2022/11/xxx040-512_78628-356x356.png)
![Investigation of fullerenol-induced changes in poroelasticity of human hepatocellular carcinoma by AFM-based creep tests](https://biofullerene.com/wp-content/uploads/2022/11/icon-research2x-356x356.png)
![Aspartic acid derivatized hydroxylated fullerenes as drug delivery vehicles for docetaxel: an explorative study](https://biofullerene.com/wp-content/uploads/2022/11/4970457-middle-500x202.png)
![Study of morphological and mechanical features of multinuclear and mononuclear SW480 cells by atomic force microscopy](https://biofullerene.com/wp-content/uploads/2022/11/360_F_337277306_bOwr-500x333.jpg)
![Identification differential behavior of Gd@C 82(OH) 22 upon interaction with serum albumin using spectroscopic analysis](https://biofullerene.com/wp-content/uploads/2022/11/market-research-icon-356x356.png)
![Mono-fullerenols modulating cell stiffness by perturbing actin bundling](https://biofullerene.com/wp-content/uploads/2022/11/pressure-resistance--356x356.jpg)
![Investigation of fullerenol-induced changes in poroelasticity of human hepatocellular carcinoma by AFM-based creep tests](https://biofullerene.com/wp-content/uploads/2022/11/Breast-Website-Infog-356x356.png)
![Exploring the Inhibitory and Antioxidant Effects of Fullerene and Fullerenol on Ribonuclease A](https://biofullerene.com/wp-content/uploads/2022/11/1rnu_assembly-1-356x356.jpeg)
![Hepatoprotective effect of fullerenol/doxorubicin nanocomposite in acute treatment of healthy rats](https://biofullerene.com/wp-content/uploads/2022/11/BTOB_Oxidative_Stres-356x356.png)