Background:#nbsp;Recent studies have shown that the biological actions and toxicity of the water-soluble compound, polyhydroxyfullerene (fullerenol), are related to the concentrations present at a particular site of action. This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons.
Methods and results:#nbsp;Fullerenol at low concentrations significantly enhanced hippocampal neuron viability as tested by MTT assay and Hoechst 33342/propidium iodide double stain detection. At high concentrations, fullerenol induced apoptosis confirmed by Comet assay and assessment of caspase proteins.
Conclusion:#nbsp;These findings suggest that fullerenol promotes cell death and protects against cell damage, depending on the concentration present. The concentration-dependent effects of fullerenol were mainly due to its influence on the reduction-oxidation pathway.
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Antioxidant properties / No toxicity / Safety
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Antioxidant properties / No toxicity / Safety
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Antioxidant properties / No toxicity / Safety
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Antioxidant properties / No toxicity / Safety
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Antioxidant properties / No toxicity / Safety
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Antioxidant properties / No toxicity / Safety
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Antioxidant properties / No toxicity / Safety
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Antioxidant properties / No toxicity / Safety
Toxicity of functionalized fullerene and fullerene synthesis chemicals
Antioxidant properties / No toxicity / Safety
Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells
Antioxidant properties / No toxicity / Safety
Mechanisms of Antioxidant Activities of Fullerenols from First-Principles Calculation
Antioxidant properties / No toxicity / Safety
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Antioxidant properties / No toxicity / Safety
Effects of Fullerenols on Mouse Brain Microvascular Endothelial Cells
Antioxidant properties / No toxicity / Safety
Mechanism of ROS scavenging and antioxidant signalling by redox metallic and fullerene nanomaterials: Potential implications in ROS associated degenerative disorders
Antioxidant properties / No toxicity / Safety
Bioluminescent Enzymatic Assay as a Tool for Studying Antioxidant Activity and Toxicity of Bioactive Compounds
Antioxidant properties / No toxicity / Safety
Effects of fullerenol nanoparticles on acetamiprid induced cytoxicity and genotoxicity in cultured human lung fibroblasts
Antioxidant properties / No toxicity / Safety
Fullerenol nanoparticles: toxicity and antioxidant activity
Antioxidant properties / No toxicity / Safety
Gene expression and biochemical responses in brain of zebrafish Danio rerio exposed to organic nanomaterials: carbon nanotubes (SWCNT) and fullerenol (C60(OH)18-22(OK4))
Antioxidant properties / No toxicity / Safety
Effect of fullerenol C(60)(OH) (24) on lipid peroxidation of kidneys, testes and lungs in rats treated with doxorubicine
Antioxidant properties / No toxicity / Safety
Effects of fullerenol C60(OH)24 on the frequency of micronuclei and chromosome aberrations in CHO-K1 cells
Antioxidant properties / No toxicity / Safety
Fullerenol C60(OH)24 prevents doxorubicin-induced acute cardiotoxicity in rats
